Search results for "Retinal thinning"

showing 3 items of 3 documents

Retinal and choroidal vasculature changes associated with chronic kidney disease

2018

Retinal and choroidal microvascular changes can be related to renal impairment in hypertension and chronic kidney disease (CKD). The study examines the association between retinochoroidal parameters and renal impairment in hypertensive, non-diabetic patients. This is a cross-sectional study on Caucasian patients with systemic arterial hypertension with different levels of renal function. All subjects were studied by blood chemistry, urine examination, microalbuminuria and blood pressure. Complete eye examination was completed with swept source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) scans of macular region. Patients were divided in groups: L…

Male030204 cardiovascular system & hematologyurologic and male genital diseaseschemistry.chemical_compound0302 clinical medicineFluorescein AngiographyMiddle Agedfemale genital diseases and pregnancy complicationsSensory Systemschoroidal thickness chronic kidney disease vascular density retinal thickness swept source OCTA swept source OCT angiographyHypertensionDisease ProgressionFemalemedicine.symptomTomography Optical CoherenceAdultmedicine.medical_specialtyAdolescentFundus OculiRenal function03 medical and health sciencesCellular and Molecular NeuroscienceYoung AdultRetinal DiseasesOphthalmologymedicineHumansRenal Insufficiency ChronicRetinal thinningAgedRetrospective StudiesSettore MED/14 - Nefrologiabusiness.industryChoroidSettore MED/30 - Malattie Apparato VisivoRetinal VesselsRetinalmedicine.diseaseeye diseasesOphthalmologyBlood pressureCross-Sectional StudieschemistryBlood chemistry030221 ophthalmology & optometryAlbuminuriaMicroalbuminuriasense organsbusinessKidney disease
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Dynamics, alterations, and consequences of minimally invasive intraocular pressure elevation in rats.

2014

PURPOSE: An important, yet not exclusive, aspect of primary open angle glaucoma is elevated intraocular pressure (IOP) profiles within fluctuations and pressure peaks. The study aimed at establishing minimally invasive methods for recurrent IOP elevation in rats to investigate the impact of IOP dynamics and pathomorphologic retinal alterations during and after IOP elevation. METHODS: Intraocular pressure was elevated unilaterally in Long Evans rats to a level of ≈35 mm Hg for 1 hour in a total of 30 manipulations within 6 weeks, by using two methods: (1) suction-cup oculopression and (2) loop-adjusted oculopression. Retinal thickness (RT) was measured via optical coherence tomography (OCT),…

Retinal degenerationMaleRetinal Ganglion Cellsmedicine.medical_specialtyIntraocular pressuregenetic structuresOpen angle glaucomachemistry.chemical_compoundTonometry OcularOptical coherence tomographyOphthalmologymedicineAnimalsRats Long-EvansRetinal thinningIntraocular Pressuremedicine.diagnostic_testbusiness.industryRetinal DegenerationRetinalmedicine.diseaseeye diseasesRatsDisease Models Animalmedicine.anatomical_structureRetinal ganglion cellchemistryAnesthesiaOptic nerveDisease Progressionsense organsbusinessGlaucoma Open-AngleTomography Optical CoherenceFollow-Up StudiesInvestigative ophthalmologyvisual science
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2021

Introduction Niemann-Pick type C (NPC) is a lysosomal storage disease that is progressive and life-limiting, with an estimated incidence of 1:120,000 live births. In addition to systemic manifestation with (hepato-)splenomegaly, there are a number of neurological manifestations (ataxia, dysarthria, dementia, cataplexy, epileptic seizures, and psychiatric disorders). Characteristic is vertical supranuclear gaze palsy, which is often overlooked. Early diagnosis and start of therapy improve quality of life. This study aimed to characterize oculomotor dysfunction of NPC patients, and to provide ophthalmologic data including retinal imaging. Methods Eighteen patients with biochemically or genet…

medicine.medical_specialtyMultidisciplinaryAtaxiaVertical supranuclear gaze palsyPalsygenetic structuresbusiness.industryRetinalSaccadic maskingchemistry.chemical_compoundmedicine.anatomical_structurechemistryOphthalmologymedicinemedicine.symptomOuter nuclear layerbusinessRetinal thinningOptic discPLOS ONE
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